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AIDS 2016: TB 2016 Demands a Global Commitment to End Tuberculosis

While much of the TB 2016 meeting, held ahead of the 21st International AIDS Conference (AIDS 2016) in Durban, was devoted to the rapidly evolving science in the fight against tuberculosis (TB), the meeting also highlighted the failure of the world, including the international HIV community, to adequately respond to the TB epidemic -- which last year surpassed HIV as the leading infectious cause of death in the world.

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AIDS 2016: Shortened Regimen for MDR-TB Shows Good Results for Children

The use of a shortened 9-month treatment regimen for multidrug-resistant tuberculosis (MDR-TB), known as the "Bangladesh regimen," was shown to be successful in 83% of children and adolescents diagnosed with rifampicin-resistant TB, researchers reported at the TB 2016 meeting, held ahead of the 21st International AIDS Conference (AIDS 2016) this week in Durban. A second study presented at the meeting showed that the antibiotic levofloxacin can be used to treat MDR-TB in children.

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ASCO 2016: PD-1 Blocker Nivolumab Shows Promise for Advanced Anal Cancer

The checkpoint inhibitor nivolumab(Opdivo), a monoclonal antibody targeting the PD-1 receptor, demonstrated activity against metastatic anal cancer that in patients who did not respond to prior treatment, according to research presented at the American Society of Clinical Oncology (ASCO) annual meeting this week in Chicago. 70% of participants in this small study experienced complete or partial response or stabilized disease.

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Gardasil HPV Vaccine Reduces Occurrence of Genital Warts and Cervical Dysplasia

 

Countries that widely use a quadrivalent human papillomavirus (HPV) vaccine have seen up to a 90% reduction in HPV infections and decreases in the incidence of genital warts and cervical cell abnormalities that can lead to cancer, according to an analysis of nearly 60 studies from 9 countries presented at the European Research Organization on Genital Infection and Neoplasia and published in the May 26 edition of Clinical Infectious Diseases.

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WHO Recommends New Test and Shorter Treatment for Tuberculosis

The World Health Organization (WHO) this month released updated recommendations for a new test that can diagnose multidrug-resistant tuberculosis (MDR-TB) more rapidly, and a shorter and less expensive antibacterial regimen that can successfully treat resistant TB in 9 to 12 months.

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ASM Microbe 2016: Novel Immune Therapy GEN-003 Improves Genital Herpes

GEN-003, a therapeutic vaccine containing recombinant herpes simplex virus (HSV) antigens, showed significant antiviral activity lasting up to a year and reduced the number of genital herpes lesions and days with recurrences, researchers reported this week at the ASM Microbe 2016 meeting in Boston.

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EASL 2016: Emricasan May Improve Inflammation and Liver Function in People with Cirrhosis

The novel caspase inhibitor emricasan (IDN-6556) led to improvements in various biomarkers and decreases in MELD scores in patients with liver cirrhosis due to hepatitis C, heavy alcohol use, or other causes, which significant declines among those who started with worse liver dysfunction, according to a late-breaking presentation at the European Association for the Study of the Liver's International Liver Congress (EASL 2016) last week in Barcelona.

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FDA Approves First Long-Lasting Buprenorphine Implant for Opioid Maintenance Therapy

The U.S. Food and Drug Administration last month approved the first-ever buprenorphine implant -- to be marketed under the brand name Probuphine -- which provides a steady dose of the drug over 6 months for people who are receiving opioid substitution therapy to manage dependence or addiction.

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EASL 2016: NorUrsodeoxycholic Acid Help Rare Bile Duct Disease with No Current Treatment

A Phase 2 European trial showed that norUrsodeoxycholic acid leads to a significant reduction in serum alkaline phosphatase in people with primary sclerosing cholangitis (PSC), a rare but serious bile duct disease, according to a report presented at the European Association for the Study of the Liver's International Liver Congress (EASL 2016) last week in Barcelona.

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