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CROI 2014: Vitamin D and Rosuvastatin Improve Bone Loss in People with HIV

A combination of high-dose vitamin D and calcium may help reduce bone loss after starting antiretroviral therapy (ART), according to a presentation at the Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston. A related study found that rosuvastatin increased hip bone mineral density in HIV positive people on ART, though insulin resistance worsened.

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CROI 2014: Tenofovir Alone May Work as Well as Truvada for Pre-exposure Prophylaxis

Tenofovir used as a single agent for pre-exposure prophylaxis (PrEP) may be as effective as the Truvada (tenofovir/emtricitabine) coformulation for preventing HIV infection, which, if confirmed, could have implications for cost and access worldwide.

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Updated Perinatal ART Guidelines for Pregnant Women with HIV

The U.S. Department of Health and Human Services has updated its guidelines for use of antiretroviral drugs by pregnant women with HIV, intended both to improve the health of women and to prevent transmission of the virus to their infants during gestation or delivery.

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CROI 2014: Neurocognitive Problems, Depression, and Early ART in People with HIV

In a particularly challenging area of HIV care where research is complicated by gaps in knowledge and invasive clinical procedures, there was significant attention to neurological manifestations -- or neuroAIDS -- at this year’s Conference on Antiretroviral Agents and Chemotherapy (CROI 2014) last month in Boston.

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CROI 2014: STIs Increase Risk of HIV Infection During Pregnancy

Pregnant women in Kenya have a similar risk of HIV infection during pregnancy as women in serodiscordant couples or sex workers, but women with a history of sexually transmitted infections (STIs) had nearly a 4-fold increased risk of acute HIV infection, John Kinuthia from the University of Nairobireported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

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CROI 2014: Researchers Discuss HIV, Aging, and Frailty

People living with HIV are at greater risk of geriatric syndromes such as frailty and difficulty with daily activities than HIV negative people of the same age -- and this can have a significant effect upon their quality of life as they age, according to several studies presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

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Curbing HIV Among Drug Users Reduces AIDS and Death Among Heterosexuals

Counseling, testing, and harm reduction programs that reduce HIV transmission among people who inject drugs (PWID) as well as non-injecting drug users were associated with an overall reduction in rates of progression to AIDS and mortality among heterosexuals in U.S. cities, according to study described in the April edition of Annals of Epidemiology.

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Men with HIV Have Higher Risk of Heart Disease

HIV positive men have more extensive atherosclerosis, or build-up of plaque in their arteries, than HIV negative men after taking into account other cardiovascular risk factors, potentially raising the risk of heart attack, according to an analysis from the large MACS cohort published in the April 1 Annals of Internal Medicine.

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Studies Shed Light on Immune Responses in HIV Vaccine Trials

A specific type of antibody known as IgG3, targeting the V1V2 portion of the HIV envelope, appears to be responsible for the temporary protection against HIV infection seen in one of the only partially successful HIV vaccine trials to date, according to 2 reports in the March 19 edition of Science Translational Medicine.

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