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Coinfection

EASL 2016: Sofosbuvir/ Velpatasvir Cures 95% of HIV/HCV Coinfected People

A dual regimen of sofosbuvir plus velpatasvir was well-tolerated and highly effective against hepatitis C virus (HCV) genotypes 1 through 4 in HIV-positive people with chronic hepatitis C coinfection, according to results from the Phase 3 ASTRAL-5 trial presented at the 2016 EASL International Liver Congress last week in Barcelona.

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CROI 2016: HIV/HBV Coinfection Linked to Worse Immune Recovery and Death

HIV-positive people with hepatitis B virus (HBV) coinfection had impaired CD4 cell recovery after starting antiretroviral (ART) and a higher risk of death than those without hepatitis B, but use of ART regimens containing tenofovir significantly reduced mortality, according to a study presented at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2016)in Boston.

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IDWeek 2015: Sofosbuvir + Daclatasvir Demonstrates High Cure Rates for HIV/HCV Coinfected People

Nearly all people with HIV and genotype 1-4 HCV coinfection treated for 12 weeks with an interferon-free regimen of sofosbuvir (Sovaldi) plus daclatasvir (Daklinza) achieved sustained virological response in the ALLY-2 trial, but 8 weeks did not work as well, according to a report in the August 20 New England Journal of Medicine. Substudies presented this month at IDWeek 2015 showed that this regimen is highly effective regardless of race or specific antiretroviral regimen.

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More Than 2 Million People Worldwide Are Coinfected with HIV and Hepatitis C

Approximately 2.3 million people are living with both HIV and hepatitis C virus (HCV), about half of whom are people who inject drugs, according to a meta-analysis of nearly 800 studies published in the February 24 advance online edition of The Lancet. The analysis found that the overall likelihood of people with HIV being coinfected with HCV is about 6%, but good data are lacking for many countries.

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Antiretroviral Treatment for HIV Appears to Protect Gay Men Against Hepatitis B

HIV-positive gay and bisexual men who use effective combination antiretroviral therapy (ART) were 80% less likely to become infected with hepatitis B virus (HBV) in a large observational study reported in the October 13 Annals of Internal Medicine. The authors emphasize, however, that ART is not a substitute for hepatitis B vaccination.

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CROI 2016: Sofosbuvir/ Velpatasvir for Hepatitis C Can Be Administered with Most Antiretrovirals

Sofosbuvir/velpatasvir, a forthcoming combination that effectively treats all hepatitis C virus (HCV) genotypes, can be safely used with most boosted antiretrovirals for HIV/HCV coinfected people, according to a study presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016)last week in Boston.

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Abacavir/Lamivudine Could Be Driving Liver Damage in People with HIV/HCV Coinfection

Progression of liver fibrosis among ART-treated patients with HIV/HCV coinfection is associated with the type of nucleoside/nucleotide reverse transcriptase inhibitor (NRTI) "backbone," Canadian research published in the September 23 online edition of Clinical Infectious Diseases suggests.

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EACS 2015: Successful Hepatitis C Treatment Lowers Risk of Death for HIV/HCV Coinfected People

Hepatitis C treatment that leads to sustained virological response (SVR) -- generally regarded as a cure -- was associated with a reduced risk of liver-related death and improved overall survival in an analysis of 3500 HIV and hepatitis C virus (HCV) coinfected patients, according to a presentation at the 15th European AIDS Conference last week in Barcelona. A related study found that while some liver-related events are declining over time, liver cancer remains a risk for coinfected people.

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ICAAC 2015: Comorbidities and Mortality Among HIV-Positive and HIV/HCV Coinfected People

While illness and death due to opportunistic illnesses has declined, people living with HIV remain prone to comorbidities that contribute to hospitalization and reduced survival, according to presentations at the 55th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) last weekin San Diego. Mortality is higher among HIV-positive people coinfected with hepatitis C virus (HCV), and is associated with liver fibrosis progression, offering further evidence supporting prompt hepatitis C treatment.

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