HIV/AIDS Topics Sangamo Reports Zinc Finger Gene Therapy Leads to Long-term CD4 Cell Gains, Shrinking HIV Reservoirs
- Details
- Category: Search for a Cure
- Published on Wednesday, 15 May 2013 00:00
- Written by Liz Highleyman
An experimental gene therapy technique that modifies CD4 T-cells to protect them from viral entry produced lasting CD4 cell increases with a single infusion, as well as reduction in proviral DNA reservoirs and decreased viral load in 2 patients who underwent antiretroviral therapy (ART) interruption, according to data presented this week at the 16th Annual Meeting of the American Society of Gene and Cell Therapy in Salt Lake City.
Very Early Antiretroviral Therapy Does Not Prevent Immune Activation
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- Category: Search for a Cure
- Published on Wednesday, 15 May 2013 00:00
- Written by Liz Highleyman
People who started antiretroviral therapy (ART) during acute HIV infection and experienced sustained viral suppression saw a substantial decrease in immune activation markers on their CD8 T-cells after 2 years of treatment, but often not to the level seen in HIV negative individuals, according to a report in the April 15, 2013, Journal of Acquired Immune Deficiency Syndromes.
FDA Declines Approval of Elvitegravir and Cobicistat as Stand-alone HIV Meds
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- Category: HIV Treatment
- Published on Tuesday, 07 May 2013 00:00
- Written by Liz Highleyman
The U.S. Food and Drug Administration (FDA) has rejected approval of Gilead Sciences' integrase inhibitor elvitegravir and pharmacoenhancer cobicistat -- components of the 4-in-1 Stribild quad pill -- as single agents for treatment of HIV, the company announced last week.
Updated Opportunistic Infection Guidelines Add Info on IRIS, Hepatitis, Drug Interactions
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- Category: HIV Treatment Guidelines
- Published on Thursday, 09 May 2013 00:00
- Written by Liz Highleyman
On May 7 the National Institutes of Health, Centers for Disease Control and Prevention, and HIV Medicine Association of the Infectious Diseases Society of Americaannounced the release of revised Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, updating the previous version from 2009.
FDA Approves Efavirenz (Sustiva) for HIV+ Children Ages 3 Months to 3 Years
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- Category: HIV Treatment
- Published on Friday, 03 May 2013 00:00
- Written by Bristol-Myers Squibb
The U.S. Food and Drug Administration (FDA) announced on May 3 that it has approved a supplemental new drug application for use of efavirenz (Sustiva) by infants and young children with HIV. The new dosing recommendation includes the option to sprinkling capsule contents on food for children who are unable to swallow pills.
Efavirenz More Effective than Nevirapine for Children with HIV
- Details
- Category: Approved HIV Drugs
- Published on Thursday, 09 May 2013 00:00
- Written by Children’s Hospital of Philadelphia
HIV positive African children and adolescents treated with efavirenz (Sustiva) were less likely to experience virological failure than those using nevirapine (Viramune), according to a large comparative study published in the May 1, 2013, Journal of the American Medical Association. Nevirapine, however, is less expensive and more widely available for children in low-income countries.
Atripla Label Adds Drug Interactions with Hepatitis C Protease Inhibitors Boceprevir and Telaprevir
- Details
- Category: HIV Treatment
- Published on Friday, 26 April 2013 00:00
- Written by FDA
The U.S. Food and Drug Administration (FDA) announced this week that the product label information for Atripla -- the HIV single-tablet regimen containing efavirenz/tenofovir/emtricitabine -- has been updated to include information about drug-drug interactions with the hepatitis C virus protease inhibitors boceprevir (Victrelis) and telaprevir (Incivek or Incivo).
More Articles...
- Antiretroviral Therapy May Have Protective Effect on HIV+ Children's Hearts
- CROI 2013: Gene Therapy Studies Show Potential for HIV Control without Drugs
- CROI 2013: Growing Number of HIV+ New Yorkers Achieve Viral Load Suppression [VIDEO]
- CROI 2013: Antiretroviral Therapy Intensification plus IL-7 Does Not Reduce HIV Reservoir
- French Cohort of HIV+ People Treated Early Appear to Control Virus
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