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Hepatitis B

HBV Rebounds After Stopping Entecavir, Switching to Interferon May Help

Most hepatitis B "e" antigen (HBeAg) negative chronic hepatitis B patients relapsed after stopping treatment with the antiviral drug entecavir (Baraclude), according to a report in the May 15 online edition of Gut. A related study found that switching from entecavir to pegylated interferon increased the likelihood of HBeAg seroconversion and hepatitis B surface antigen(HBsAg) lossin HBeAg positive patients.

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Everolimus Did Not Improve Survival for Advanced Liver Cancer Patients

The mTOR inhibitor everolimus (Afinator) failed to increase overall survival for people with advanced hepatocellular carccinoma (HCC) who were previously unsuccessfully treated with sorafenib, according to results from the EVOLVE-1 trial published in the July 2 edition of JAMA.

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Prevention Task Force Recommends Hepatitis B Screening for People at High Risk

The U.S. Preventive Services Task Force (USPSTF) last week issued a new recommendation for hepatitis B virus (HBV) screening of non-pregnant adolescents and adults without current symptoms of viral hepatitis. The task force called for screening of people at high risk for infection including people with HIV, gay and bisexual men, and people who inject drugs.

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No Tenofovir Resistance Seen In 2 Years of Hepatitis B Treatment

No cases of resistance to tenofovir (Viread) were detected among chronic hepatitis B patients with prior resistance to lamivudine (3TC or Epivir) through 96 weeks of treatment, according to a study described in the June 11 advance edition of Clinical Gastroenterology and Hepatology. Adding emtricitabine (Emtriva) did not improve effectiveness compared with tenofovir alone.

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DDW 2014: Some Hepatitis B Patients Can Stop Antiviral Treatment without Relapse

Stopping antiviral therapy after several years appears generally safe for people with HBeAg negative chronic hepatitis B without liver cirrhosis, and a substantial proportion do not experience viral relapse or worsening liver inflammation while off treatment, according to a pair of posters presented at the Digestive Disease Week (DDW 2014) meeting this week in Chicago.

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Antiviral Treatment for Hepatitis B Lowers Risk of Liver Cancer

Antiviral therapy for chronic hepatitis B virus (HBV) infection can reduce the risk of developing hepatocellular carcinoma (HCC), even among people with high HBV viral load, according to research described in the May 2014 edition of Clinical Gastroenterology and Hepatology.

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May Is Hepatitis Awareness Month

May is Hepatitis Awareness Month in the U.S., an opportunity to promote better understanding of viral hepatitis and to encourage more people to get tested and receive care for hepatitis B and C. Hepatitis Testing Day is coming up on May 19.

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Screening and Post-Natal Prophylaxis Reduce Mother-to-Child HBV Transmission

Prenatal screening of pregnant women for hepatitis B virus (HBV), followed by immune prophylaxis for infants using injected hepatitis B antibodies and the first dose of the HBV vaccine given soon after delivery, resulted in a low rate of vertical HBV transmission -- less than 1 per 100 births -- in a real-world study described in the May 27 advance edition of Annals of Internal Medicine.

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EASL 2014: Long-term Tenofovir Maintains Viral Suppression in People with Hepatitis B

Treatment with tenofovir (Viread) for 3 years remained effective in keeping hepatitis B virus (HBV) suppressed, normalizing liver inflammation, and potentially reducing liver disease progression, according to studies from Germany, France, and Spain presented at the 49thEASL International Liver Congress (EASL 2014) recently held in London.

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