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Experimental HCV Drugs

EASL 2015: Merck Hepatitis C Combination Achieves 90% Cure in Advanced Cirrhosis Patients

A 12-week course of treatment with 2 direct-acting antivirals in development by Merck cured hepatitis C virus infection in 90% of people with very advanced cirrhosis and at imminent risk of liver failure, Ira Jacobson of Weill Cornell Medical College reported at the European Association for the Study of the Liver (EASL) 50th International Liver Congress this week in Vienna. The Phase 2 study looked at the use of the HCV protease inhibitor grazoprevir and the NS5A inhibitor elbasvir in people with Child-Pugh B cirrhosis.

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EASL 2015: Merck HCV Combination Effective after Failure of First Generation Direct-Acting Antivirals

Treatment for 12 weeks with grazoprevir and elbasvir, 2 direct-acting antivirals being development by Merck, plus ribavirin, cured 95% of people with hepatitis C who had experienced failure of a previous combination containing an HCV protease inhibitor, Xavier Forns of the University of Barcelona Hospital Clinic reported the at the European Association for the Study of the Liver (EASL) 50th International Liver Congress this week in Vienna.

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Janssen Interferon-Free Regimen with Simeprevir Cures Most Patients with Genotype 1 HCV

A 12-week all-oral regimen containing the FDA-approved HCV protease inhibitor simeprevir (Olysio) plus 2 investigational direct-acting antivirals drugs being developed by Janssen cured up to 95% of people with genotype 1 hepatitis C, according to study findings presented at the Asian Pacific Association for the Study of the Liver (APASL) conference last month in Istanbul.

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Allergy Drug Inhibits Hepatitis C Virus Replication in Mouse Study

The over-the-counter allergy medication chlorcyclizine HCl, or CCZ, was found to be a potent inhibitor of hepatitis C virus (HCV) genotype 1b and 2a replication, according to a laboratory study described in the April 8 edition of Science Translational Medicine. The study authors suggest that this older drug could potentially be an affordable component of combination treatment. A Phase 1 clinical trial is now underway.

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FDA Will Consider Approval of Daclatasvir for Genotype 3 Hepatitis C Treatment

The U.S. Food and Drug Administration (FDA) has accepted Bristol-Myers Squibb's application for approval of stand-alone daclatasvir (Daklinza) for the treatment of genotype 3 hepatitis C virus (HCV), to be used in combination with sofosbuvir (Sovaldi), the company announced last week.

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